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Molecular Epidemiology of Macrolide and Tetracycline Resistances in Commensal Gemella sp. Isolates
- Source :
- Antimicrobial Agents and Chemotherapy. 51:1487-1490
- Publication Year :
- 2007
- Publisher :
- American Society for Microbiology, 2007.
-
Abstract
- The epidemiologic relatedness of 29 erythromycin-resistant Gemella sp. strains from normal flora, characterized previously, were evaluated by pulsed-field gel electrophoresis (PFGE). Three isolates carried the tet (O) gene and the tet (M) gene. The msr (A) gene was found in two Gemella morbillorum strains in combination with the erm (B) or mef (E) gene. The sequences of the mef (A/E ) , erm (B), and msr (A) genes showed a high similarity to the corresponding sequences of other gram-positive cocci. All the strains harboring the mef (A/E) gene and the msr (D) gene possessed open reading frame 3 (ORF3)/ORF6. The 16 G. morbillorum isolates represented 15 distinct DNA profiles. Four clusters were identified (≥80% genetic relatedness). The 12 Gemella haemolysans strains belonged to different PFGE types. The clonal diversity found suggests that horizontal transfer may be the main route through which erythromycin resistance is acquired.
- Subjects :
- Tetracycline
Molecular Sequence Data
Biology
Gemella morbillorum
Staphylococcaceae
Microbiology
stomatognathic system
Mechanisms of Resistance
Drug Resistance, Bacterial
Genotype
medicine
Pulsed-field gel electrophoresis
Pharmacology (medical)
Gene
Phylogeny
Antibacterial agent
Pharmacology
Genetics
Molecular Epidemiology
Molecular epidemiology
Tetracycline Resistance
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Electrophoresis, Gel, Pulsed-Field
Infectious Diseases
Gemella
Macrolides
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....647a4e044b0f910c69421a97210e10e8