Back to Search
Start Over
Novel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out
- Source :
- Nanomaterials, TECNALIA Publications, Fundación Tecnalia Research & Innovation, Nanomaterials, Vol 11, Iss 902, p 902 (2021), Volume 11, Issue 4
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute (MDPI), 2021.
-
Abstract
- The UV-nanoimprint lithography(UV-NIL) fabrication of a novel network of micron-sized channels, forming an open channel microfluidic system is described. Details about the complete manufacturing process, from mastering to fabrication in small batches and in high throughput with up to 1200 micro titer plates per hour is presented. Deep insight into the evaluation of a suitable UV-curable material, mr-UVCur26SF is given, presenting cytotoxic evaluation, cell compatibility tests and finally a neuronal assay. The results indicate how the given pattern, in combination with the resist, paves the way to faster, cheaper, and more reliable drug screening. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement NO. 646260. The research was also partially supported by NextGenMicrofluidics project under HORIZON2020 with grant agreement no 862092.
- Subjects :
- Materials science
Fabrication
General Chemical Engineering
Microfluidics
Nanotechnology
02 engineering and technology
Article
Neuronal cell assay
Nanoimprint lithography
law.invention
lcsh:Chemistry
03 medical and health sciences
law
R2R UV-NIL
General Materials Science
Lithography
Throughput (business)
030304 developmental biology
0303 health sciences
Manufacturing process
021001 nanoscience & nanotechnology
Titer
Resist
lcsh:QD1-999
0210 nano-technology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nanomaterials, TECNALIA Publications, Fundación Tecnalia Research & Innovation, Nanomaterials, Vol 11, Iss 902, p 902 (2021), Volume 11, Issue 4
- Accession number :
- edsair.doi.dedup.....645859e69006b6bf75b4830d5a8296d5