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T lymphocyte control of autoreactivity: analysis with human T cell clones and limiting dilution culture
- Source :
- European Journal of Immunology. 16:1433-1438
- Publication Year :
- 1986
- Publisher :
- Wiley, 1986.
-
Abstract
- To investigate cellular mechanisms controlling activated autoreactive T lymphocytes, a limiting dilution system was established employing cloned autoreactive major his-tocompatibility complex class II specific lymphocytes (a2/7) as stimulator cells for autologous peripheral blood mononuclear cells. At low responder/stimulator ratios, cytotoxic effector cells were generated capable of lysing clone a2/7. Importantly, within the population of cells mediating autocytotoxic effector function, differential specificities were found to exist. The generation of such autocytotoxic T lymphocytes appears to be inhibited by an additional population of cells circulating at lower frequency suggesting that autoreactivity is controlled at distinct levels by discrete functional cellular subsets.
- Subjects :
- Cytotoxicity, Immunologic
education.field_of_study
T-Lymphocytes
T cell
Immunology
Population
Histocompatibility Antigens Class II
Cell Communication
T lymphocyte
Biology
T-Lymphocytes, Regulatory
Peripheral blood mononuclear cell
Clone Cells
Cell biology
medicine.anatomical_structure
Cell–cell interaction
Cell culture
Immune Tolerance
medicine
Humans
Immunology and Allergy
Cytotoxic T cell
Clone (B-cell biology)
education
Subjects
Details
- ISSN :
- 15214141 and 00142980
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi.dedup.....64568e02828e9fc9da21fccc0be91e66