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Quantitative assessment of erector spinae muscles in patients with Mycobacterium avium complex lung disease

Authors :
Hirofumi Kamata
Yohei Funatsu
Shoji Suzuki
Satoshi Okamori
Naoki Hasegawa
Akihiko Ozaki
Ho Namkoong
Kazuma Yagi
Masahiro Jinzaki
Tatsuya Kusumoto
Yoshitake Yamada
Makoto Ishii
Takanori Asakura
Yuki Niijima
Masahiro Hashimoto
Tomoko Betsuyaku
Source :
Respiratory medicine. 145
Publication Year :
2018

Abstract

Background and objective No reports exist regarding skeletal muscle involvement in patients with Mycobacterium avium complex lung disease (MAC-LD). The cross-sectional area of the erector spinae muscles (ESMCSA) reflects physical activity and can be assessed by computed tomography (CT). We investigated the relationship between ESMCSA and physiological parameters and prognosis in MAC-LD patients. Material and methods In this prospective observational study, the ESMCSA was measured on single-slice axial CT images. MAC-LD patients and sex- and age-matched controls (non-MAC-LD participants) were evaluated. We evaluated the relationship between the ESMCSA and physiological parameters and prognosis. Results A total of 260 patients (209 female; median age, 69 years; 190 with nodular/bronchiectatic disease; 74 with cavitary lesions) were enrolled. The ESMCSA was not different between MAC-LD patients and controls. In MAC-LD patients, the ESMCSA was significantly associated with age, body mass index (BMI), pulmonary function, CT severity, and health-related quality of life (HRQL). Multivariate Cox proportional hazards analyses revealed that an ESMCSA Conclusions Although the prognostic impact was limited, ESMCSA was significantly associated with HRQL and prognostic physiological parameters, such as BMI and pulmonary function.

Details

ISSN :
15323064
Volume :
145
Database :
OpenAIRE
Journal :
Respiratory medicine
Accession number :
edsair.doi.dedup.....645506eeaf4b3a82077f717648d401a9