Back to Search
Start Over
Non-enzymatic electrochemical detection of glucose with a disposable paper-based sensor using a cobalt phthalocyanine-ionic liquid-graphene composite
- Source :
- Biosensorsbioelectronics. 102
- Publication Year :
- 2017
-
Abstract
- We introduce for the first time a paper-based analytical device (PAD) for the non-enzymatic detection of glucose by modifying a screen-printed carbon electrode with cobalt phthalocyanine, graphene and an ionic liquid (CoPc/G/IL/SPCE). The modifying composite was characterized by UV-visible spectroscopy, energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The disposable devices show excellent conductivity and fast electron transfer kinetics. The results demonstrated that the modified electrode on PADs had excellent electrocatalytic activity towards the oxidation of glucose with NaOH as supporting electrolyte (0.1M). The oxidation potential of glucose was negatively shifted to 0.64V vs. the screen-printed carbon pseudo-reference electrode. The paper-based sensor comprised a wide linear concentration range for glucose, from 0.01 to 1.3mM and 1.3-5.0mM for low and high concentration of glucose assay, respectively, with a detection limit of 0.67µM (S/N = 3). Additionally, the PADs were applied to quantify glucose in honey, white wine and human serum. The disposable, efficient, sensitive and low-cost non-enzymatic PAD has great potential for the development of point-of-care testing (POCT) devices that can be applied in healthcare monitoring.
- Subjects :
- Blood Glucose
Paper
Materials science
Indoles
Scanning electron microscope
Supporting electrolyte
Inorganic chemistry
Biomedical Engineering
Biophysics
Analytical chemistry
Ionic Liquids
Wine
02 engineering and technology
Biosensing Techniques
01 natural sciences
law.invention
Electron transfer
chemistry.chemical_compound
law
Limit of Detection
Electrochemistry
Organometallic Compounds
Humans
Electrodes
Detection limit
Graphene
010401 analytical chemistry
General Medicine
Electrochemical Techniques
Equipment Design
Honey
021001 nanoscience & nanotechnology
0104 chemical sciences
Glucose
chemistry
Transmission electron microscopy
Ionic liquid
Electrode
Graphite
0210 nano-technology
Food Analysis
Biotechnology
Subjects
Details
- ISSN :
- 18734235
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Biosensorsbioelectronics
- Accession number :
- edsair.doi.dedup.....6451d5156cb442618e9d32baa6a3b56c