Back to Search
Start Over
Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15
- Source :
- International Journal of Obesity. 40:193-197
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Anorexia-cachexia associated with cancer and other diseases is a common and often fatal condition representing a large area of unmet medical need. It occurs most commonly in advanced cancer and is probably a consequence of molecules released by tumour cells, or tumour-associated interstitial or immune cells. These may then act directly on muscle to cause atrophy and/or may cause anorexia, which then leads to loss of both fat and lean mass. Although the aetiological triggers for this syndrome are not well characterized, recent data suggest that MIC-1/GDF15, a transforming growth factor-beta superfamily cytokine produced in large amounts by cancer cells and as a part of other disease processes, may be an important trigger. This cytokine acts on feeding centres in the hypothalamus and brainstem to cause anorexia leading to loss of lean and fat mass and eventually cachexia. In animal studies, the circulating concentrations of MIC-1/GDF15 required to cause this syndrome are similar to those seen in patients with advanced cancer, and at least some epidemiological studies support an association between MIC-1/GDF15 serum levels and measures of nutrition. This article will discuss its mechanisms of central appetite regulation, and the available data linking this action to anorexia-cachexia syndromes that suggest it is a potential target for therapy of cancer anorexia-cachexia and conversely may also be useful for the treatment of severe obesity.
- Subjects :
- 0301 basic medicine
Cachexia
Growth Differentiation Factor 15
Endocrinology, Diabetes and Metabolism
media_common.quotation_subject
medicine.medical_treatment
Appetite
Medicine (miscellaneous)
Disease
Anorexia
Weight Gain
Transforming Growth Factor beta1
03 medical and health sciences
Atrophy
Neoplasms
medicine
Animals
Humans
Molecular Targeted Therapy
Obesity
media_common
Nutrition and Dietetics
business.industry
digestive, oral, and skin physiology
Cancer
medicine.disease
Gene Expression Regulation, Neoplastic
030104 developmental biology
Cytokine
Immunology
GDF15
medicine.symptom
Energy Metabolism
business
Biomarkers
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....64508461ab2ab8518e770c783e992e8d
- Full Text :
- https://doi.org/10.1038/ijo.2015.242