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Protein-polysaccharide nanohybrids: Hybridization techniques and drug delivery applications
- Source :
- European Journal of Pharmaceutics and Biopharmaceutics. 133:42-62
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Complex nanosystems fabricated by hybridization of different types of materials such as lipids, proteins, or polysaccharides are usually superior to simple ones in terms of features and applications. Proteins and polysaccharides hold great potential for development of nanocarriers for drug delivery purposes based on their unique biocompatibility, biodegradability, ease of functionalization, improved biodistribution and minimal toxicity profiles. Protein-polysaccharide nanohybrids have gained a lot of attention in the past few years particularly for drug delivery applications. In this review, different hybridization techniques utilized in the fabrication of such nanohybrids including electrostatic complexation, Maillard conjugation, chemical coupling and electrospinning were thoroughly reviewed. Moreover, various formulation factors affecting the characteristics of the formed nanohybrids were discussed. We also reviewed in depth the outcomes of such hybridization ranging from stability enhancement, to toxicity reduction, improved biocompatibility, and drug release modulation. We also gave an insight on their limitations and what hinders their clinical translation and market introduction.
- Subjects :
- Biodistribution
Biocompatibility
Pharmaceutical Science
Nanotechnology
02 engineering and technology
010402 general chemistry
Polysaccharide
01 natural sciences
Drug Delivery Systems
Polysaccharides
Animals
Humans
Technology, Pharmaceutical
chemistry.chemical_classification
Drug Carriers
Chemistry
Proteins
General Medicine
Toxicity reduction
021001 nanoscience & nanotechnology
Electrospinning
0104 chemical sciences
Drug delivery
Nanoparticles
Surface modification
Nanocarriers
0210 nano-technology
Biotechnology
Subjects
Details
- ISSN :
- 09396411
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmaceutics and Biopharmaceutics
- Accession number :
- edsair.doi.dedup.....64487d4864a6fd453a48af28f1bef12a