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Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:695-699
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.
- Subjects :
- Models, Molecular
Clinical Biochemistry
Pharmaceutical Science
RRNA binding
Mass spectrometry
medicine.disease_cause
Biochemistry
Chemical synthesis
Mass Spectrometry
Structure-Activity Relationship
RNA, Ribosomal, 16S
Drug Discovery
Escherichia coli
medicine
Base Pairing
Molecular Biology
Binding Sites
biology
Chemistry
Organic Chemistry
Ribosomal RNA
16S ribosomal RNA
biology.organism_classification
Affinities
RNA, Bacterial
Nucleic Acid Conformation
Molecular Medicine
Benzimidazoles
Bacteria
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....64409800d7b0a0fe54dd00f8ee5fcdbc