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Anti-inflammatory potential of thienopyridines as possible alternative to NSAIDs
- Source :
- European Journal of Pharmacology. 678:48-54
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- The present study was designed to evaluate the anti-inflammatory and antiarthritic activity of the new synthetic thienopyridine analogs. The anti-inflammatory activity of thienopyridines was assayed by using carrageenan; dextran and arachidonic acid induced paw edema models (acute), cotton pellet granuloma model (Sub acute) and Freund's complete adjuvant induced arthritis (chronic) in experimental rats. The compounds BN-4, BN-14 and BN-16 have shown significant inhibition of edema in carrageenan and arachidonic acid induced paw edema model at a dose of 100 mg/kg compared to the dextran induced paw edema model and also showed significant inhibition in granuloma tissue formation and Freund's complete adjuvant induced arthritis in experimental rats. These thienopyridine analogs also inhibited the proinflammatory mediators such as Tumor necrosis factor (TNF)-α, Interleukin (IL)-1β and Nitric Oxide (NO) in Lipopolysaccharide (LPS) challenged murine macrophages. Ulcerogenecity study results revealed less ulcerogenic potential of BN-4, BN-14 and BN-16 compared to nonsteroidal anti-inflammatory drug (NSAID) indomethacin in rats. In conclusion, the new thienopyridine analogs were promising for the potential use as anti-inflammatory agents for both acute and chronic inflammatory disorders with low toxic effects.
- Subjects :
- Male
Thienopyridines
Thienopyridine
Indomethacin
Drug Evaluation, Preclinical
Arthritis
Pharmacology
Cell Line
Nitric oxide
Proinflammatory cytokine
Mice
chemistry.chemical_compound
Edema
Animals
Medicine
Stomach Ulcer
Rats, Wistar
Granuloma
business.industry
Macrophages
Anti-Inflammatory Agents, Non-Steroidal
medicine.disease
Arthritis, Experimental
Rats
Carrageenan
Disease Models, Animal
Dextran
chemistry
Immunology
Cytokines
Arachidonic acid
medicine.symptom
business
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 678
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....643c0c65684f81862509f10e5a59f396