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Developing a High-Throughput Assay for the Integral Membrane Glycerol 3-Phosphate Acyltransferase
- Source :
- ASSAY and Drug Development Technologies. 17:267-274
- Publication Year :
- 2019
- Publisher :
- Mary Ann Liebert Inc, 2019.
-
Abstract
- Phospholipid biosynthesis begins with the acylation of glycerol 3-phosphate (G3P). In most Gram-positive bacteria including many pathogens, a membrane protein called PlsY is the only acylt...
- Subjects :
- 030226 pharmacology & pharmacy
Acylation
Structure-Activity Relationship
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Drug Development
Drug Discovery
Glycerol
Glycerol 3 phosphate acyltransferase
Enzyme Inhibitors
Phospholipid biosynthesis
030304 developmental biology
0303 health sciences
Bacteria
Dose-Response Relationship, Drug
Molecular Structure
biology
Cell Membrane
biology.organism_classification
High-Throughput Screening Assays
Aquifex
Membrane
Membrane protein
chemistry
Biochemistry
Glycerol-3-Phosphate O-Acyltransferase
Molecular Medicine
lipids (amino acids, peptides, and proteins)
Lysophospholipids
Subjects
Details
- ISSN :
- 15578127 and 1540658X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- ASSAY and Drug Development Technologies
- Accession number :
- edsair.doi.dedup.....6437b38e1fbf1074ed9f57758d4228e2
- Full Text :
- https://doi.org/10.1089/adt.2019.935