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Rhinovirus infections in infancy and early childhood
- Source :
- European Respiratory Journal, The European respiratory journal : official journal of the European Society for Clinical Respiratory
- Publication Year :
- 2012
- Publisher :
- European Respiratory Society (ERS), 2012.
-
Abstract
- Rhinovirus (RV) infections occur early and recurrently in life, imposing a significant burden of disease on infants and young children. They are the most frequent causative agents of both upper and lower respiratory tract infections in this age group and are associated with a broad variety of clinical outcomes, ranging from asymptomatic infections to severe respiratory disease requiring hospitalisation. In addition to their impact on short-term morbidity, RVs are also debated as important pathogens in the development of recurrent wheeze and/or asthma. Several studies in infants at high-risk for atopy and asthma and in hospitalised children have demonstrated that recurrent wheezing illnesses induced by RVs early in life are a risk factor for the development of asthma later in childhood. However, underlying mechanisms are poorly understood. The question whether RVs are directly involved in the development of childhood wheeze and asthma, or whether symptomatic RV infections only represent a proxy for infants prone to develop obstructive lung diseases, is still open. In this review we provide an overview on the role of RVs as important disease-causing agents from infancy to early childhood and discuss their contribution to the subsequent development of childhood wheeze and/or asthma.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Pediatrics
medicine.medical_specialty
medicine.disease_cause
Asymptomatic
Atopy
03 medical and health sciences
0302 clinical medicine
Risk Factors
Wheeze
medicine
Humans
030212 general & internal medicine
Early childhood
Respiratory Tract Infections
Respiratory Sounds
Asthma
Inflammation
Picornaviridae Infections
Respiratory tract infections
business.industry
Respiratory disease
Infant
medicine.disease
3. Good health
Hospitalization
030228 respiratory system
Child, Preschool
Female
Rhinovirus
medicine.symptom
business
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....6430c0dba06fe0d0ddcdb8dbd0c417bd