Back to Search
Start Over
The effect of ε-aminocaproyl-S-benzyl-L-cysteine on the t-PA activity of human saliva
- Source :
- Advances in medical sciences. 56(2)
- Publication Year :
- 2011
-
Abstract
- Purpose The aim of this work was to study the effect of the synthetic antifibrinolytics: e-aminocaproic acid (EACA), tranexamic acid (AMCHA) and e-aminocaproyl-S-benzyl-L-cysteine (H-EACA-S-Bzl-L-Cys-OH) on the fibrinolytic activity of saliva in order to obtain new data on the activity of saliva tissue plasminogen activator (t-PA). Material and Methods Saliva samples were obtained from healthy volunteers. Saliva, precipitate and supernatant were tested 1hr, 4 hrs and 6hrs after collection. The effect of the synthetic antifibrinolytics was examined with the use of the clot lysis time determination. Results All examined compounds inhibited the fibrinolytic activity of saliva 1hr after collection. H-EACA-S-Bzl-L-Cys-OH was the most active inhibitor. After 6 hours in room temperature only this compound showed a certain possibility to prolong the clot lysis time. Conclusions The obtained results may indicate the possibility of the difference in specificity between the activities of t-PA of saliva and recombinant tissue plasminogen activator activities. It may explain the unexpected high inhibitory activity of H-EACA-S-Bzl-L-Cys-OH in our study.
- Subjects :
- Saliva
Time Factors
medicine.medical_treatment
Hemorrhage
Pharmacology
Tissue plasminogen activator
Models, Biological
Healthy volunteers
Fibrinolysis
medicine
Animals
Humans
Cysteine
Recombinant tissue plasminogen activator
Blood Coagulation
Aminocaproates
business.industry
Clot lysis time
Fibrinogen
General Medicine
S-benzyl-L-cysteine
Antifibrinolytic Agents
Biochemistry
Tranexamic Acid
Tissue Plasminogen Activator
Aminocaproic Acid
Cattle
business
Peptides
Tranexamic acid
medicine.drug
Subjects
Details
- ISSN :
- 18984002
- Volume :
- 56
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Advances in medical sciences
- Accession number :
- edsair.doi.dedup.....642cb50d3fabbbe2d81c5ede96574703