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Resistant maltodextrin promotes fasting glucagon-like peptide-1 secretion and production together with glucose tolerance in rats
- Source :
- British Journal of Nutrition. 114:34-42
- Publication Year :
- 2015
- Publisher :
- Cambridge University Press (CUP), 2015.
-
Abstract
- Glucagon-like peptide-1 (GLP-1), which is produced and released from enteroendocrine L cells, plays pivotal roles in postprandial glycaemia. The ingestion of resistant maltodextrin (RMD), a water-soluble non-digestible saccharide, improves the glycaemic response. In the present study, we examined whether the continuous feeding of RMD to rats affected GLP-1 levels and glycaemic control. Male Sprague–Dawley rats (6 weeks of age) were fed an American Institute of Nutrition (AIN)-93G-based diet containing either cellulose (5 %) as a control, RMD (2·5 or 5 %), or fructo-oligosaccharides (FOS, 2·5 or 5 %) for 7 weeks. During the test period, an intraperitoneal glucose tolerance test (IPGTT) was performed after 6 weeks. Fasting GLP-1 levels were significantly higher in the 5 % RMD group than in the control group after 6 weeks. The IPGTT results showed that the glycaemic response was lower in the 5 % RMD group than in the control group. Lower caecal pH, higher caecal tissue and content weights were observed in the RMD and FOS groups. Proglucagon mRNA levels were increased in the caecum and colon of both RMD and FOS groups, whereas caecal GLP-1 content was increased in the 5 % RMD group. In addition, a 1 h RMD exposure induced GLP-1 secretion in an enteroendocrine L-cell model, and single oral administration of RMD increased plasma GLP-1 levels in conscious rats. The present study demonstrates that continuous ingestion of RMD increased GLP-1 secretion and production in normal rats, which could be stimulated by its direct and indirect (enhanced gut fermentation) effects on GLP-1-producing cells, and contribute to improving glucose tolerance.
- Subjects :
- Blood Glucose
Male
Glucagon-like peptide-1
medicine.medical_specialty
Colon
Enteroendocrine Cells
Medicine (miscellaneous)
Enteroendocrine cell
Proglucagon
Rats, Sprague-Dawley
Caecum
Glucagon-Like Peptide 1
Polysaccharides
Oral administration
Internal medicine
medicine
Animals
Ingestion
RNA, Messenger
Cecum
Glucose tolerance test
Nutrition and Dietetics
medicine.diagnostic_test
biology
Chemistry
digestive, oral, and skin physiology
Glucose tolerance
Fasting
Glucose Tolerance Test
Hydrogen-Ion Concentration
biology.organism_classification
Diet
Rats
Endocrinology
Postprandial
Fermentation
Fructo-oligosaccharides
Digestion
Resistant maltodextrin
Subjects
Details
- ISSN :
- 14752662 and 00071145
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....642aa2fc571fd3de3d0b02c2c376b664