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The long-term impact of biliopancreatic diversion on glycemic control in the severely obese with type 2 diabetes mellitus in relation to preoperative duration of diabetes
- Source :
- Surgery for Obesity and Related Diseases. 12:345-349
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Bariatric surgery has been shown to be effective in severely obese patients with type 2 diabetes mellitus (T2DM).Evaluate the long-term efficacy of biliopancreatic diversion (BPD) for the treatment of T2DM depending on the preoperative duration of T2DM.University Hospital.Retrospective analysis investigating 2 subsets of severely obese patients who had undergone BPD from 1984 to 1995. The first included 52 patients with a preoperative T2DM duration of ~1 year (SD group - 49 on oral agents and 3 on insulin), and the second included 68 patients who had been diabetic for5 years before BPD (LD group - 52 on oral agents and 16 on insulin). Postoperatively, T2DM was regarded as in remission when fasting serum glucose (FSG) was lower than 100 mg/dL on regular diet and without antidiabetic therapy.In the SD patients, the number of individuals without T2DM remission were lower both at 5-10 (0/31, 0% of patients, versus 8/54, 15% of patients, p.04) and at15 years (1/28, 3% of patients, versus 10/41, 24% of patients, p.0012). Furthermore, after BPD, the number of patients with dyslipidemia strongly reduced (p.001) in both groups, values at 5-10 years remaining very similar to those observed at15 years.These results indicate that severely obese patients with longer T2DM duration have a worse metabolic outcome maintained at long and very long term following BPD.
- Subjects :
- Adult
Blood Glucose
Male
obesity
medicine.medical_specialty
Time Factors
endocrine system diseases
bariatric surgery
medicine.medical_treatment
030209 endocrinology & metabolism
Type 2 diabetes
03 medical and health sciences
0302 clinical medicine
obesity, type 2 diabetes, bariatric surgery
Diabetes mellitus
Weight Loss
Humans
Insulin
Medicine
030212 general & internal medicine
Biliopancreatic Diversion
Retrospective Studies
Glycemic
Glycated Hemoglobin
business.industry
Blood Glucose Self-Monitoring
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
University hospital
Obesity, Morbid
Surgery
Diabetes Mellitus, Type 2
Preoperative Period
Female
type 2 diabetes
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15507289
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Surgery for Obesity and Related Diseases
- Accession number :
- edsair.doi.dedup.....63ee012a6eb085e36fb08b0b43ec4c3f