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An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity
- Source :
- JACC. Basic to translational science, vol 2, iss 1, Beak, J; Huang, W; Parker, JS; Hicks, ST; Patterson, C; Simpson, PC; et al.(2017). An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity.. JACC. Basic to translational science, 2(1), 39-53. doi: 10.1016/j.jacbts.2016.10.006. UCSF: Retrieved from: http://www.escholarship.org/uc/item/11z122s7, JACC: Basic to Translational Science, Vol 2, Iss 1, Pp 39-53 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Summary: Alpha-1 adrenergic receptors (α1-ARs) play adaptive and protective roles in the heart. Dabuzalgron is an oral selective α1A-AR agonist that was well tolerated in multiple clinical trials of treatment for urinary incontinence, but has never been used to treat heart disease in humans or animal models. In this study, the authors administered dabuzalgron to mice treated with doxorubicin (DOX), a widely used chemotherapeutic agent with dose-limiting cardiotoxicity that can lead to heart failure (HF). Dabuzalgron protected against DOX-induced cardiotoxicity, likely by preserving mitochondrial function. These results suggest that activating cardiac α1A-ARs with dabuzalgron, a well-tolerated oral agent, might represent a novel approach to treating HF. Key Words: alpha adrenergic receptors, anthracyclines, cardioprotection, catecholamines, heart failure
- Subjects :
- 0301 basic medicine
Agonist
lcsh:Diseases of the circulatory (Cardiovascular) system
alpha
Heart disease
medicine.drug_class
heart failure
receptors
Adrenergic
030204 cardiovascular system & hematology
Pharmacology
Article
03 medical and health sciences
0302 clinical medicine
medicine
Receptor
anthracyclines
Cardioprotection
Cardiotoxicity
business.industry
medicine.disease
Alpha-1A adrenergic receptor
3. Good health
030104 developmental biology
lcsh:RC666-701
cardioprotection
Heart failure
adrenergic
Cardiology and Cardiovascular Medicine
business
catecholamines
Subjects
Details
- ISSN :
- 2452302X
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- JACC: Basic to Translational Science
- Accession number :
- edsair.doi.dedup.....63eddc7a9d6873a0911ea187e47443ab