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Vertebral fracture prevalence and measurement of the scanographic bone attenuation coefficient on CT-scan in patients with systemic sclerosis
- Source :
- Rheumatology International, Rheumatology International, Springer Verlag, 2018, 38 (10), pp.1901-1910. ⟨10.1007/s00296-018-4139-5⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; To study vertebral fracture (VF) prevalence and the scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1) on computed tomography scans (CT-scans) in systemic sclerosis patients. This monocentric retrospective study included patients followed from 2000 to 2014 and fulfilling ACR/EULAR 2013 criteria for systemic sclerosis and who underwent a thoracic or thoraco-abdomino-pelvic CT-scan during their follow-up. Clinical characteristics for sclerosis and osteoporosis risk factors were collected. For CT-scan, the VFs were determined according to Genant’s classification, the SBAC-L1 was measured in Hounsfield Units (HU), and a SBAC-L1 ≤ 145 HU (fracture threshold) defined patients at VF risk. Predictive factors for SBAC-L1 ≤ 145 HU were studied. A total of 70 patients were included [mean age, 62.3 (± 15.6) years, women 88.5%, diffuse sclerosis 22.9% (n = 16)]. On CT-scans, three VFs were detected in three patients (4.3%). The mean SBAC-L1 was 157.26 HU (± 52.1), and 35 patients (50%) presented a SBAC-L1 ≤ 145 HU. In multivariate analysis, only age (especially patients older than 63 years, OR = 1.08, CI 95% 1.04–1.13, p = 0.001) and calcinosis (OR = 6.04, CI 95% 1.27–28.70, p = 0.02) were independently associated with a SBAC-L1 ≤ 145 HU. On a large sample of patients with systemic sclerosis, the VF prevalence on CT-scan was low (4.3%) while 50% of the patients presented a SBAC-L1 ≤ 145 HU. Interestingly, the presence of calcinosis, periarticular calcifications or acro-osteolysis was linked with low SBAC-L1 and should lead to an osteoporosis screening, especially for patients under 63 years old.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
Immunology
Osteoporosis
Computed tomography
03 medical and health sciences
0302 clinical medicine
Absorptiometry, Photon
Rheumatology
Calcinosis
Bone Density
Internal medicine
Hounsfield scale
medicine
Prevalence
Immunology and Allergy
Humans
In patient
030212 general & internal medicine
Aged
Retrospective Studies
030203 arthritis & rheumatology
Lumbar Vertebrae
Scleroderma, Systemic
medicine.diagnostic_test
business.industry
Retrospective cohort study
Middle Aged
medicine.disease
3. Good health
Spinal Fractures
Female
Radiology
business
Tomography, X-Ray Computed
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- Language :
- English
- ISSN :
- 01728172 and 1437160X
- Database :
- OpenAIRE
- Journal :
- Rheumatology International, Rheumatology International, Springer Verlag, 2018, 38 (10), pp.1901-1910. ⟨10.1007/s00296-018-4139-5⟩
- Accession number :
- edsair.doi.dedup.....63e3adc0a47dbc71764102efa9b60683