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The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field
- Source :
- International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3859
- Publication Year :
- 2022
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2022.
-
Abstract
- The induction of apoptosis is one of the main goals of the designed anti-cancer therapies. In recent years, increased attention has been paid to the physical factors such as magnetic fields and to the natural bioactive compounds and the possibilities using them in medicine. Hence, the aim of this study was to evaluate the anti-tumor effect of caffeic or chlorogenic acid in combination with a moderate-strength static magnetic field on C32 melanoma cells by assessing the effect of both factors on the apoptotic process. The apoptosis of the C32 cells was evaluated using a flow cytometry analysis. The expression of the apoptosis-associated genes was determined using the RT-qPCR technique. The caspase activity and the concentration of the oxidative damage markers were also measured. It was found that phenolic acids and a static magnetic field trigger the apoptosis of the C32 cells and also affect the expression of the genes encoding the apoptosis regulatory proteins. In conclusion, our study indicated that both of the phenolic acids and a static magnetic field can be used supportively in the treatment of melanoma and that caffeic acid is more pro-apoptotic than chlorogenic acid.
- Subjects :
- Organic Chemistry
General Medicine
Catalysis
Antioxidants
Computer Science Applications
Inorganic Chemistry
Oxidative Stress
Caffeic Acids
Magnetic Fields
Humans
apoptosis
polyphenols
static magnetic field
cancer cells
chlorogenic acid
caffeic acid
Physical and Theoretical Chemistry
Chlorogenic Acid
Molecular Biology
Melanoma
Spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3859
- Accession number :
- edsair.doi.dedup.....63dda6c520f7d0fc3f29abc529480823
- Full Text :
- https://doi.org/10.3390/ijms23073859