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Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars
- Source :
- J. Mater. Chem. B. 2:4862-4867
- Publication Year :
- 2014
- Publisher :
- Royal Society of Chemistry (RSC), 2014.
-
Abstract
- Although various studies related to nanoparticles-based photothermal therapy have been actively performed, an epoch-making photothermolysis therapy exhibiting both high selectivity and efficiency has yet not been discovered. For the first time, we have developed novel valuable therapeutic complexes, namely, dual aptamer-modified gold nanostars, for the targeting of prostate cancers, including PSMA(+) and PSMA(−) cells. The synthesized probes were characterized through several techniques, including UV-VIS spectral analysis, DLS analysis, zeta potential measurements, and TEM imaging, and were subsequently subjected to cytotoxicity tests, cell uptake confirmation, and in vitro photothermal therapy. The homogeneously well-fabricated nanostars presented high selectivity to prostate cancer cells and extremely high efficiency for therapy using an 808 nm laser under an irradiance of 0.3 W cm−2, which is lower than the permitted value for skin exposure (0.329 W cm−2). It is anticipated that this novel photothermal agent will become the general platform for targeted therapy.
- Subjects :
- Materials science
medicine.medical_treatment
Aptamer
Biomedical Engineering
Nanoparticle
Nanotechnology
General Chemistry
General Medicine
Photothermal therapy
medicine.disease
Targeted therapy
Prostate cancer
medicine.anatomical_structure
Prostate
medicine
Zeta potential
Biophysics
General Materials Science
Cytotoxicity
Subjects
Details
- ISSN :
- 20507518 and 2050750X
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- J. Mater. Chem. B
- Accession number :
- edsair.doi.dedup.....63d194fdd8648442535f36c785ecd3cd