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High frequency of Epstein-Barr virus in Chinese peripheral T-cell lymphoma
- Source :
- Aarhus University, Zhou, X G, Hamilton-Dutoit, S J, Yan, Q H & Pallesen, G 1994, ' High frequency of Epstein-Barr virus in Chinese peripheral T-cell lymphoma ' Histopathology, vol. 24, no. 2, pp. 115-22 .
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Abstract
- Forty-two cases of Chinese T-cell lymphoma were studied for expression of Epstein-Barr virus (EBV) encoded RNA (EBER-1) and EBV latent membrane protein-1 (LMP-1) using in situ hybridization and immunohistochemistry, respectively. EBV was detected in tumour cells in 24/39 peripheral T-cell lymphomas (62%), comprising 18/27 pleomorphic, medium and large cell lymphomas (67%), 4/6 angioimmunoblastic lymphadenopathy-like lymphomas (67%), 2/2 Lennert's lymphomas, 0/2 anaplastic large cell lymphomas, and 0/2 T-zone lymphomas. EBV was not found in three T-lymphoblastic lymphomas. EBV was associated with 12/24 nodal (50%) compared with 12/15 extranodal (80%) peripheral T-cell lymphomas. In EBV positive nodal lymphomas, 9/12 cases (75%) contained less than 10% EBER positive tumour cells. In EBV positive extranodal lymphomas, 9/11 cases (82%) showed EBV gene expression in more than 50% of the tumour cells, and in five of these almost all tumour cells were positive. Lymphomas of the nasopharynx (mainly midline granuloma-type) showed EBER-1 expression in nearly all tumour cells. LMP-1 was detected in 19/23 EBER positive peripheral T-cell lymphomas (83%). Our results show that EBV is strongly associated with peripheral T-cell lymphomas in Chinese. An important role for the virus is suggested in lymphomas of the nasopharynx. The significance of EBV in T-cell lymphomas that contain only a minor population of virally infected tumour cells is currently unclear.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
China
Herpesvirus 4, Human
Histology
Adolescent
T cell
Population
medicine.disease_cause
Pathology and Forensic Medicine
Immunoenzyme Techniques
Viral Matrix Proteins
immune system diseases
hemic and lymphatic diseases
medicine
Gammaherpesvirinae
T-cell lymphoma
Humans
education
Antigens, Viral
In Situ Hybridization
Aged
education.field_of_study
biology
Large cell
Lymphoma, T-Cell, Peripheral
General Medicine
Middle Aged
medicine.disease
biology.organism_classification
Epstein–Barr virus
Peripheral T-cell lymphoma
Lymphoma
medicine.anatomical_structure
RNA, Viral
Female
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Aarhus University, Zhou, X G, Hamilton-Dutoit, S J, Yan, Q H & Pallesen, G 1994, ' High frequency of Epstein-Barr virus in Chinese peripheral T-cell lymphoma ' Histopathology, vol. 24, no. 2, pp. 115-22 .
- Accession number :
- edsair.doi.dedup.....63cb05c4dbac658e2afd39fa1deaa403