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Predictive Value of Age-Adjusted Charlson Co-Morbidity Index for 1-, 3-, and 5-Year Mortality in Patients Requiring Transcatheter Mitral Valve Repair
- Source :
- The American Journal of Cardiology. 120:309-314
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Co-morbidities increase markedly with aging, and they often negatively affect its prognosis. Although mortality with transcatheter mitral valve repair (TMVr) is significantly less than for open mitral valve surgery in patients at high surgical risk, it remains a concern to identify which patients will benefit from this treatment. Some prognostic metrics have been reported to guide better patient selection; however, universal risk stratification measures have not been established. This study aimed to determine if age-adjusted Charlson co-morbidity index (CCI) could predict mortality in patients who underwent TMVr and to assess its discriminatory performance in long-term outcomes. We retrospectively reviewed 222 patients who underwent TMVr, and 7 who died in hospital was excluded. Cox proportional hazard models were applied to select the demographic characteristics that were associated with cumulative mortality. Receiver-operating characteristic analyses were performed for predicting all-cause mortality, and discriminatory performance was assessed. We found that the age-adjusted CCI (hazard ratio 1.33, 95% confidence interval 1.16 to 1.51, p
- Subjects :
- Male
Cardiac Catheterization
medicine.medical_specialty
Time Factors
Age adjustment
Comorbidity
030204 cardiovascular system & hematology
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Mitral valve
medicine
Humans
Hospital Mortality
030212 general & internal medicine
Aged
Retrospective Studies
Heart Valve Prosthesis Implantation
Mitral regurgitation
business.industry
MitraClip
Hazard ratio
Age Factors
Virginia
Mitral Valve Insufficiency
Atrial fibrillation
Retrospective cohort study
Prognosis
medicine.disease
Confidence interval
medicine.anatomical_structure
ROC Curve
Cardiology
Mitral Valve
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- The American Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....63c562d267a67288043708944744260f