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Plasma citrulline is a marker of absorptive small bowel length in patients with transient enterostomy and acute intestinal failure
- Source :
- Clinical Nutrition, Clinical Nutrition, Elsevier, 2010, 29 (2), pp.235-242. ⟨10.1016/j.clnu.2009.08.010⟩
- Publication Year :
- 2010
- Publisher :
- HAL CCSD, 2010.
-
Abstract
- Small bowel disruption is often complicated by acute intestinal failure and can be corrected by chyme reinfusion (CR). Plasma citrulline ([Cit]) is a biomarker of the enterocyte mass. Our aim was to determine whether [Cit] could be a marker of absorptive intestinal mass or function by assessing whether CR could affect intestinal absorptive function and [Cit].Twenty-six patients with small bowel disruption and double enterostomy were treated with CR. Fecal wet weight, nitrogen and fat absorption, parenteral nutrition delivery and [Cit] were measured before and after the initiation of CR with a median follow-up of 30 days.CR decreased the intestinal wet weight output (median+/-IQ, 2384+/-969 vs. 216+/-242mLd(-1), P0.0001) and parenteral nutrition dependence (65% vs. 8%, P0.01). CR was associated with a rise in net nitrogen and fat digestive absorption and [Cit] (17.0+/-10.0 vs. 31.0+/-12.0micromolL(-1), P=0.0001). Before the initiation of CR, [Cit] correlated positively with the absorptive post-duodenal small bowel length (r=0.39, P=0.04), but not with the total post-duodenal small bowel length (r=0.11, P=0.60).CR allows for a dramatic improvement of intestinal absorptive function and a near doubling in [Cit] level. [Cit] is not a marker of overall intestinal mass, but of the absorptive small bowel function.
- Subjects :
- Male
030309 nutrition & dietetics
Critical Care and Intensive Care Medicine
Gastroenterology
Severity of Illness Index
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Intestinal failure
Blood plasma
Intestine, Small
Citrulline
ComputingMilieux_MISCELLANEOUS
0303 health sciences
Nutrition and Dietetics
Enterostomy
Middle Aged
Short bowel syndrome
INTESTINAL FAILURE
Gastrointestinal Contents
3. Good health
medicine.anatomical_structure
Acute Disease
030211 gastroenterology & hepatology
Female
Adult
CITRULLINE
medicine.medical_specialty
Adolescent
Enterocyte
Nutritional Status
CHYME REINFUSION
03 medical and health sciences
Young Adult
Enteral Nutrition
SHORT BOWEL SYNDROME
Internal medicine
medicine
Humans
Aged
business.industry
medicine.disease
Small intestine
Intestinal Diseases
Parenteral nutrition
Enterocytes
chemistry
Intestinal Absorption
business
Biomarkers
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- Language :
- English
- ISSN :
- 02615614
- Database :
- OpenAIRE
- Journal :
- Clinical Nutrition, Clinical Nutrition, Elsevier, 2010, 29 (2), pp.235-242. ⟨10.1016/j.clnu.2009.08.010⟩
- Accession number :
- edsair.doi.dedup.....63bbb10a8dc8950434a6b13322623a12