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Plasma lipoprotein(a) levels are associated with the severity of coronaryheart disease in Han Chinese people
- Source :
- Turkish journal of medical sciences. 46(4)
- Publication Year :
- 2015
-
Abstract
- Background/aim The aim of this study was to investigate the association of lipoprotein(a) [Lp(a)] with the severity of coronary heart disease (CHD) in Han Chinese people. Materials and methods Six hundred and seventy-nine patients with angiographically defined CHD were enrolled in this cross-sectional study. Fasting lipids were measured, and the severity of CHD was quantitatively assessed for each patient according to the number of stenotic coronary branches and the Gensini scoring system. Results The levels of Lp(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and apolipoprotein (apo) B100 increased, while high-density lipoprotein cholesterol (HDL-C) and apoAI decreased significantly with the number of stenotic vessels. The levels of Lp(a) increased and HDL-C and apoAI decreased significantly with the Gensini scores. The logistic regression analyses showed that Lp(a) and HDL-C were independently associated with the number of stenotic coronary vessels after adjusting for age, weight, body mass index, sex, smoking, alcohol consumption, hypertension, diabetes, triglycerides, TC, LDL-C, VLDL-C, apoAI, and apoB100. However, only Lp(a) was independently associated with the Gensini scores after adjustment. Conclusion Our data indicate that Lp(a) might be a useful marker in predicting the severity of coronary heart disease.
- Subjects :
- medicine.medical_specialty
Apolipoprotein B
030204 cardiovascular system & hematology
Logistic regression
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes mellitus
Blood plasma
medicine
Humans
030212 general & internal medicine
Triglycerides
biology
business.industry
Cholesterol
Cholesterol, HDL
General Medicine
Lipoprotein(a)
Cholesterol, LDL
medicine.disease
Cross-Sectional Studies
chemistry
biology.protein
Cardiology
lipids (amino acids, peptides, and proteins)
business
Body mass index
Lipoprotein
Subjects
Details
- ISSN :
- 13000144
- Volume :
- 46
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Turkish journal of medical sciences
- Accession number :
- edsair.doi.dedup.....63b5fc063da0852f40535f09ac3dbdff