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Role of oxidative stress in experimental sepsis and multisystem organ dysfunction
- Source :
- Free Radical Research. 40:665-672
- Publication Year :
- 2006
- Publisher :
- Informa UK Limited, 2006.
-
Abstract
- Massive increase in radical species can lead to oxidative stress, promoting cell injury and death. This review focuses on experimental evidence of oxidative stress in critical illnesses, sepsis and multisystem organ dysfunction. Oxidative stress could negatively affect organ injury and thus overall survival of experimental models. Based on this experimental evidence, we could improve the rationale of supplementation of antioxidants alone or in combination with standard therapies aimed to reduce oxidative stress as novel adjunct treatment in critical care.
- Subjects :
- Pathology
medicine.medical_specialty
Reactive oxygen species metabolism
medicine.disease_cause
Bioinformatics
Biochemistry
Antioxidants
Sepsis
medicine
Overall survival
Animals
Humans
Respiratory Distress Syndrome
business.industry
Organ dysfunction
Cell injury
General Medicine
medicine.disease
Disease Models, Animal
Oxidative Stress
Critical illness
medicine.symptom
Reactive Oxygen Species
business
Oxidative stress
Subjects
Details
- ISSN :
- 10292470 and 10715762
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Free Radical Research
- Accession number :
- edsair.doi.dedup.....63b06f557555a0943249d75d572ce77b