Back to Search Start Over

The Association of MMP7 Genotype With Pterygium

Authors :
Cheng Hsi Liao
Da Tian Bau
Chia-Wen Tsai
Chien Chih Yu
Ning-Yi Hsia
Jai Sing Yang
Meng Feng Wu
Pei Shin Hu
Wen Shin Chang
Yun Chi Wang
Source :
In Vivo. 34:51-56
Publication Year :
2019
Publisher :
Anticancer Research USA Inc., 2019.

Abstract

Background/Aim: In literature, few studies have examined the diagnostic or prognostic potential of matrix metalloproteinases (MMP) in pterygium, whose formation and progression are closely related to imbalance in the extracellular microenvironment. In this study, we investigated the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to pterygium risk. Materials and Methods: A total of 134 cases and 268 controls were collected and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The AA, AG and GG genotypes at MMP7 promoter A-181G were non-significantly differentially distributed between the two groups at 85.8, 11.2 and 3.0%, respectively, in pterygium cases and 88.4, 9.7 and 1.9% in controls, respectively (p for trend=0.6822). There was no polymorphic genotype for MMP7 C-153T among our Taiwanese cohort. Conclusion: A-181G and C-153T genotypes at MMP7 do not have a direct role in determining Taiwanese susceptibility to pterygium.

Details

ISSN :
17917549 and 0258851X
Volume :
34
Database :
OpenAIRE
Journal :
In Vivo
Accession number :
edsair.doi.dedup.....63af655b3144e426101a51130b46cb54
Full Text :
https://doi.org/10.21873/invivo.11744