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The Association of MMP7 Genotype With Pterygium
- Source :
- In Vivo. 34:51-56
- Publication Year :
- 2019
- Publisher :
- Anticancer Research USA Inc., 2019.
-
Abstract
- Background/Aim: In literature, few studies have examined the diagnostic or prognostic potential of matrix metalloproteinases (MMP) in pterygium, whose formation and progression are closely related to imbalance in the extracellular microenvironment. In this study, we investigated the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to pterygium risk. Materials and Methods: A total of 134 cases and 268 controls were collected and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The AA, AG and GG genotypes at MMP7 promoter A-181G were non-significantly differentially distributed between the two groups at 85.8, 11.2 and 3.0%, respectively, in pterygium cases and 88.4, 9.7 and 1.9% in controls, respectively (p for trend=0.6822). There was no polymorphic genotype for MMP7 C-153T among our Taiwanese cohort. Conclusion: A-181G and C-153T genotypes at MMP7 do not have a direct role in determining Taiwanese susceptibility to pterygium.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Genotype
Biology
Pterygium
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Gastroenterology
MMP7
General Biochemistry, Genetics and Molecular Biology
Asian People
Gene Frequency
Risk Factors
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Promoter Regions, Genetic
Aged
Aged, 80 and over
Pharmacology
Middle Aged
Prognosis
Case-Control Studies
Matrix Metalloproteinase 7
Cohort
Female
Polymorphism, Restriction Fragment Length
Research Article
Subjects
Details
- ISSN :
- 17917549 and 0258851X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- In Vivo
- Accession number :
- edsair.doi.dedup.....63af655b3144e426101a51130b46cb54
- Full Text :
- https://doi.org/10.21873/invivo.11744