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Mechanisms of genome instability induced by RNA-processing defects
- Source :
- Trends in genetics : TIG. 30(6)
- Publication Year :
- 2014
-
Abstract
- The role of normal transcription and RNA processing in maintaining genome integrity is becoming increasingly appreciated in organisms ranging from bacteria to humans. Several mutations in RNA biogenesis factors have been implicated in human cancers, but the mechanisms and potential connections to tumor genome instability are not clear. Here, we discuss how RNA-processing defects could destabilize genomes through mutagenic R-loop structures and by altering expression of genes required for genome stability. A compelling body of evidence now suggests that researchers should be directly testing these mechanisms in models of human cancer.
- Subjects :
- Genetics
Genome instability
RNA Stability
RNA Splicing
RNA
Biology
Genome
Genomic Instability
Article
Transcriptome
Enhancer Elements, Genetic
Gene Expression Regulation
Transcription (biology)
Neoplasms
RNA splicing
Animals
Humans
Nucleic Acid Conformation
RNA Processing, Post-Transcriptional
Gene
Subjects
Details
- ISSN :
- 01689525
- Volume :
- 30
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Trends in genetics : TIG
- Accession number :
- edsair.doi.dedup.....63ad6ee905d646bc33112e0f2eb529cc