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Mechanisms of genome instability induced by RNA-processing defects

Authors :
Yujia Alina Chan
Philip Hieter
Peter C. Stirling
Source :
Trends in genetics : TIG. 30(6)
Publication Year :
2014

Abstract

The role of normal transcription and RNA processing in maintaining genome integrity is becoming increasingly appreciated in organisms ranging from bacteria to humans. Several mutations in RNA biogenesis factors have been implicated in human cancers, but the mechanisms and potential connections to tumor genome instability are not clear. Here, we discuss how RNA-processing defects could destabilize genomes through mutagenic R-loop structures and by altering expression of genes required for genome stability. A compelling body of evidence now suggests that researchers should be directly testing these mechanisms in models of human cancer.

Details

ISSN :
01689525
Volume :
30
Issue :
6
Database :
OpenAIRE
Journal :
Trends in genetics : TIG
Accession number :
edsair.doi.dedup.....63ad6ee905d646bc33112e0f2eb529cc