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Spectrum of postmortem autopsy findings in native and surgically corrected hearts with congenital malformations: a 10-year single-center experience
- Source :
- Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 51
- Publication Year :
- 2020
-
Abstract
- Objectives We reviewed a spectrum of congenital heart defects assessed in our center between 1/2010 and 4/2020, evaluated their gross anatomy, assessed the age distribution, evaluated performed surgical procedures, and correlated gross and ultrasound findings. Methods All necroptic cases and explanted hearts that underwent specialized cardiac autopsy were included in this study. Autopsy findings including gross description of congenital heart defects together with echocardiographic findings were retrospectively assessed. In surgically corrected hearts, the operation records were included as well. All congenital heart defects and surgical procedures were subclassified into main and additional category. Results The study included 92 necroptic cases of live-born children, 7 stillbirths, 2 cases of young adults, 50 induced abortions, and 5 explanted hearts, with median age 36 weeks. The most frequently encountered leading congenital heart defects were hypoplastic left heart syndrome, aortic stenosis, septal defects, or persistent arterial trunk. Fifty-one patients underwent surgical repair represented mainly by valvuloplasties, aortoplasty, and procedures leading to univentricular circulation. In the native hearts, 4 postnatal and 16 abortion/stillbirth cases showed discordance between gross and sonographic findings, mainly attributed to missed ventricular septal defect. Gestational age of the discordant group was significantly lower compared to the concordant group (P= .007). Conclusions Autopsy continues to provide essential information about the morphology of congenital heart defects. However, the encountered congenital heart defects were usually complex, often surgically corrected or evaluated as a result of induced abortion or still birth. Cardiac autopsy therefore places high demands on pathologists with regards to proper gross heart assessment. It is also an invaluable part of quality control in prenatal cardiology.
- Subjects :
- 0301 basic medicine
Adult
Heart Defects, Congenital
Male
medicine.medical_specialty
Adolescent
Autopsy
Gestational Age
030204 cardiovascular system & hematology
Abortion
Single Center
Pathology and Forensic Medicine
Hypoplastic left heart syndrome
03 medical and health sciences
Young Adult
0302 clinical medicine
Age Distribution
Fetal Heart
Prenatal Diagnosis
Medicine
Humans
Cardiac Surgical Procedures
Child
Retrospective Studies
Arterial trunk
business.industry
Myocardium
Infant, Newborn
Gestational age
Infant
Abortion, Induced
General Medicine
Stillbirth
medicine.disease
Surgery
Stenosis
030104 developmental biology
Echocardiography
Child, Preschool
Gross anatomy
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 18791336
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
- Accession number :
- edsair.doi.dedup.....63aa78a995fcae6f0c5ddd77f6599afa