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Co-current crossflow microfiltration in a microchannel
- Source :
- Biomedical Microdevices 21 (2019) 1, Biomedical Microdevices, 21(1)
- Publication Year :
- 2019
-
Abstract
- Steady state crossflow microfiltration (CMF) is an important and often necessary means of particle separation and concentration for both industrial and biomedical processes. The factors controlling the performance of CMF have been extensively reviewed. A major factor is transmembrane pressure (TMP). Because microchannels have small height, they tend to have high pressure gradients in the feed-flow direction. In the extreme, these gradients may even reverse the pressure across the membrane (inciting backflow). It is therefore desirable to compensate for the effect of feed-flow on the TMP, aiming at constant transmembrane pressure (cTMP) at a value which maximizes filtrate flux. This is especially critical during filtration of deformable particles (e.g. erythrocytes) through low intrinsic resistance membranes. Filtration flux is generally taken to be directly proportional to TMP, with pressure drop along the channel decreasing in the flow direction. A co-current flow of filtrate in a suitably designed filtrate collecting channel is shown to allow the TMP to remain constant and permit the sieving surface to perform optimally, permitting up to twice as much filtration over that of a naïve configuration. Manipulation of the filtrate channel may be even more beneficial if it prevents backflow that might otherwise occur at the end of a sufficiently long channel. Experiments with erythrocyte suspensions, reported here, validate these concepts.
- Subjects :
- Microfiltration model
Materials science
Erythrocytes
Sieve
Microfiltration
Microfluidics
Biomedical Engineering
02 engineering and technology
01 natural sciences
Microsieve
law.invention
Nanopores
Plasma
law
Pressure
Molecular Biology
Filtration
Backflow
VLAG
Pressure drop
Cross-flow
Steady state
Microchannel
010401 analytical chemistry
Organic Chemistry
Water
Membranes, Artificial
Mechanics
Equipment Design
Models, Theoretical
021001 nanoscience & nanotechnology
Organische Chemie
Constant transmembrane pressure
0104 chemical sciences
Membrane
Blood
Current (fluid)
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 13872176
- Database :
- OpenAIRE
- Journal :
- Biomedical Microdevices 21 (2019) 1, Biomedical Microdevices, 21(1)
- Accession number :
- edsair.doi.dedup.....63a8f791d81bc77f5919ffa9e773a155