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Clinical Benefits of Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma
- Source :
- Applied Sciences, Vol 11, Iss 1882, p 1882 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Recent success of systemic therapeutic agents, including combination immunotherapy, could promote a change in the treatment strategy in patients with advanced hepatocellular carcinoma (HCC). Although hepatic arterial infusion chemotherapy (HAIC) is a treatment option for advanced HCC in Japan, it is not recommended by other guidelines. We discuss the clinical benefits of HAIC compared to sorafenib. The clinical benefits of HAIC are as follows: (1) even a patient with Child–Pugh B HCC (7 or 8 points) is a candidate for HAIC (2) Child–Pugh scores barely decline with the use of HAIC compared with sorafenib (3) HAIC is highly effective in patients with vascular invasion compared with sorafenib; and (4) survival in patients receiving HAIC may not be associated with skeletal muscle volume. In contrast, the disadvantages are problems related with the reservoir system. HAIC has clinical benefits in a subpopulation of patients without extrahepatic metastasis with Child–Pugh A HCC and vascular invasion (especially primary branch invasion or main portal vein invasion) or with Child–Pugh B HCC.
- Subjects :
- Oncology
Sorafenib
medicine.medical_specialty
hepatic arterial infusion chemotherapy
lcsh:Technology
Vascular invasion
Reservoir system
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Internal medicine
Hepatic arterial infusion chemotherapy
medicine
General Materials Science
In patient
vascular invasion
Instrumentation
neoplasms
lcsh:QH301-705.5
Fluid Flow and Transfer Processes
business.industry
lcsh:T
Process Chemistry and Technology
General Engineering
medicine.disease
digestive system diseases
lcsh:QC1-999
Computer Science Applications
lcsh:Biology (General)
lcsh:QD1-999
lcsh:TA1-2040
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Extrahepatic metastasis
Main portal vein
030211 gastroenterology & hepatology
sorafenib
advanced hepatocellular carcinoma
business
lcsh:Engineering (General). Civil engineering (General)
lcsh:Physics
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20763417
- Volume :
- 11
- Issue :
- 1882
- Database :
- OpenAIRE
- Journal :
- Applied Sciences
- Accession number :
- edsair.doi.dedup.....63a1cbcea9fd9c7f95bc0a074febc8df