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Spinopelvic alignment predicts disc calcification, displacement, and Modic changes: Evidence of an evolutionary etiology for clinically-relevant spinal phenotypes
- Source :
- JOR Spine, JOR Spine, Vol 3, Iss 1, Pp n/a-n/a (2020)
- Publication Year :
- 2019
-
Abstract
- Lumbar disc‐displacement, Modic changes (MCs), and UTE Disc Sign (UDS) on MRI are clinically relevant spinal phenotypes that can lead to sciatica/LBP. Not all degenerated discs result in disc‐displacement, MCs and UDS, suggesting varied etiologies. Spinopelvic parameters have been implicated in various spinal disorders. Pelvic incidence (PI) is “fixed parameter” since skeletal maturity. No study has addressed disc‐displacement, MCs and UDS in context of spinopelvic parameters. Therefore, the aim of study was to determine if spinopelvic parameters are associated and predict clinically‐relevant MRI‐phenotypes. One hundred and eight population‐based subjects (mean age: 52.3 years) were recruited. Spondylolisthesis and scoliosis individuals were excluded. Lumbar lordosis (LL), PI, sacral slope (SS), and pelvic tilt (PT) were assessed on lateral plain radiographs. Disc degeneration was assessed and summated, and presence or not of disc‐displacement and MCs were noted on T2W MRI. UDS was detected on UTE. Following exclusion criteria, 95 subjects were assessed. Disc‐displacement (82.1%), MCs (52.6%), and UDS (37.9%) were associated with lower PI, SS, LL, and LL/PI index. On multivariate analyses, lower PI was significantly related to development of these MRI phenotypes (adjusted OR range:0.95‐0.92; P<br />Our findings suggest a strong biomechanical influence of spinopelvic morphometry on clinically meaningful anterior column spinal phenotypes, which may have an etiological foundation in spinal evolution secondary to permanent bipedalism. Our results improve the understanding of spinal phenotypes, contributing additional steps toward personalized spine care.
- Subjects :
- sacral slope
medicine.medical_specialty
Lordosis
Population
Urology
Context (language use)
Scoliosis
Modic
ultra‐short
lordosis
tilt
Lumbar
lcsh:Orthopedic surgery
medicine
Orthopedics and Sports Medicine
pelvic
education
Research Articles
lumbar
Sciatica
education.field_of_study
business.industry
Modic changes
medicine.disease
Spondylolisthesis
lcsh:RD701-811
spinopelvic alignment
incidence
UTE
medicine.symptom
business
Research Article
MRI
Subjects
Details
- ISSN :
- 25721143
- Volume :
- 3
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- JOR spine
- Accession number :
- edsair.doi.dedup.....63953d986982d5ece7e3c4bc8028c1f0