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Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials
- Source :
- The American Journal of Clinical Nutrition. 91:480-486
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- BACKGROUND The effect of isoflavone on endothelial function in postmenopausal women is controversial. OBJECTIVE The objective of this study was to evaluate the effect of oral isoflavone supplementation on endothelial function, as measured by flow-mediated dilation (FMD), in postmenopausal women. DESIGN A meta-analysis of randomized placebo-controlled trials was conducted to evaluate the effect of oral isoflavone supplementation on endothelial function in postmenopausal women. Trials were searched in PubMed, Embase, the Cochrane Library database, and reviews and reference lists of relevant articles. Summary estimates of weighted mean differences (WMDs) and 95% CIs were obtained by using random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. RESULTS A total of 9 trials were reviewed in the present meta-analysis. Overall, the results of the 9 trials showed that isoflavone significantly increased FMD (WMD: 1.75%; 95% CI: 0.83%, 2.67%; P = 0.0002). Meta-regression analysis indicated that the age-adjusted baseline FMD was inversely related to effect size. Subgroup analysis showed that oral supplementation of isoflavone had no influence on FMD if the age-adjusted baseline FMD was > or = 5.2% (4 trials; WMD: 0.24%; 95% CI: -0.94%, 1.42%; P = 0.69). This improvement seemed to be significant when the age-adjusted baseline FMD levels were
- Subjects :
- medicine.medical_specialty
Endothelium
Medicine (miscellaneous)
Subgroup analysis
Cochrane Library
Placebo
Gastroenterology
Placebos
chemistry.chemical_compound
Oral administration
Internal medicine
Humans
Medicine
Randomized Controlled Trials as Topic
Gynecology
Nutrition and Dietetics
business.industry
Middle Aged
Isoflavones
medicine.disease
Postmenopause
Vasodilation
Menopause
medicine.anatomical_structure
chemistry
Cardiovascular Diseases
Meta-analysis
Dietary Supplements
Female
Endothelium, Vascular
business
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- The American Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....639233c07d5b7bc77345f3fe95b007ff