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Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation
- Source :
- Microbial Cell, Vol 3, Iss 8, Pp 302-328 (2016), Microbial Cell
- Publication Year :
- 2016
- Publisher :
- Shared Science Publishers OG, 2016.
-
Abstract
- Diploid budding yeast (Saccharomyces cerevisiae) can adopt one of several alternative differentiation fates in response to nutrient limitation, and each of these fates provides distinct biological functions. When different strain backgrounds are taken into account, these various fates occur in response to similar environmental cues, are regulated by the same signal transduction pathways, and share many of the same master regulators. I propose that the relationships between fate choice, environmental cues and signaling pathways are not Boolean, but involve graded levels of signals, pathway activation and master-regulator activity. In the absence of large differences between environmental cues, small differences in the concentration of cues may be reinforced by cell-to-cell signals. These signals are particularly essential for fate determination within communities, such as colonies and biofilms, where fate choice varies dramatically from one region of the community to another. The lack of Boolean relationships between cues, signaling pathways, master regulators and cell fates may allow yeast communities to respond appropriately to the wide range of environments they encounter in nature.
- Subjects :
- 0301 basic medicine
sporulation
Applied Microbiology
030106 microbiology
Saccharomyces cerevisiae
pseudohyphal growth
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Microbiology
Applied Microbiology and Biotechnology
03 medical and health sciences
Pseudohyphal growth
cell-cell signals
Virology
Genetics
meiosis
quiescence
Molecular Biology
Sensory cue
lcsh:QH301-705.5
yeast communities
biology
Ecology
Cell Biology
biology.organism_classification
Budding yeast
Yeast
Boolean logic
lcsh:Biology (General)
Evolutionary biology
Parasitology
Signal transduction
Subjects
Details
- Language :
- English
- ISSN :
- 23112638
- Volume :
- 3
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Microbial Cell
- Accession number :
- edsair.doi.dedup.....638bb3070b845c5c9ccd734eb5dfc06e