Back to Search
Start Over
Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- The appearance of adaptive immunity in jawed vertebrates is termed the immunological ‘Big Bang’ because of the short evolutionary time over which it developed. Underlying it is the recombination activating gene (RAG)-based V(D)J recombination system, which initiates the sequence diversification of the immunoglobulins and lymphocyte antigen receptors. It was convincingly argued that the RAG1 and RAG2 genes originated from a single transposon. The current dogma postulates that the V(D)J recombination system was established by the split of a primordial vertebrate immune receptor gene into V and J segments by a RAG1/2 transposon, in parallel with the domestication of the same transposable element in a separate genomic locus as the RAG recombinase. Here, based on a new interpretation of previously published data, we propose an alternative evolutionary hypothesis suggesting that two different elements, a RAG1/2 transposase and a Transib transposon invader with RSS-like terminal inverted repeats, co-evolved to work together, resulting in a functional recombination process. This hypothesis offers an alternative understanding of the acquisition of recombinase function by RAGs and the origin of the V(D)J system.
- Subjects :
- Transposable element
Inverted repeat
Genes, RAG-1
Immunology
transposons
Biology
Recombination-activating gene
Evolution, Molecular
03 medical and health sciences
0302 clinical medicine
RAG2
Hypothesis and Theory
Recombinase
Immunology and Allergy
Animals
Humans
Transposase
030304 developmental biology
Genetics
0303 health sciences
adaptive immune system evolution
V(D)J recombination
immunological big bang
hemic and immune systems
RC581-607
RSS
V(D)J Recombination
guns for hire
DNA-Binding Proteins
terminal inverted repeats
DNA Transposable Elements
RAG1
Immunologic diseases. Allergy
Recombination
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....637b1cdb9883a712a8600c52a53480a0