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Ovarian cancer of endometrioid type as part of the MSH6 gene mutation phenotype
- Source :
- Journal of Human Genetics. 47:0529-0531
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- The MSH6 gene is one of the DNA mismatch repair genes involved in development of inherited cancers, predominantly of the colorectum and endometrium. Herein we describe the first Polish MSH6 family and the pathological and clinical data about the ovarian cancer diagnosed in the proband. Our results and reports by others indicate that, besides colorectal and endometrial cancer, the late-onset endometrioid type of ovarian cancer can be a feature of families with MSH6 germline mutations.
- Subjects :
- Proband
congenital, hereditary, and neonatal diseases and abnormalities
Base Pair Mismatch
Colorectal cancer
DNA Mutational Analysis
Gene mutation
Germline mutation
Genetics
medicine
Humans
Genetic Predisposition to Disease
neoplasms
Germ-Line Mutation
Genetics (clinical)
Aged
Aged, 80 and over
Ovarian Neoplasms
business.industry
Endometrial cancer
nutritional and metabolic diseases
Cancer
DNA, Neoplasm
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
digestive system diseases
Pedigree
DNA-Binding Proteins
MSH6
Phenotype
Cancer research
Female
Ovarian cancer
business
Carcinoma, Endometrioid
Microsatellite Repeats
Subjects
Details
- ISSN :
- 1435232X and 14345161
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....637a9b084c65d9c6c26eaf80ccb65ac4