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Pharmacology and clinical applications of selective estrogen receptor modulators
- Source :
- Climacteric. 12:188-205
- Publication Year :
- 2009
- Publisher :
- Informa UK Limited, 2009.
-
Abstract
- Compounds that can be described as selective estrogen receptor modulators (SERMs) have expanded dramatically over the past two decades. The ability of SERMs to act as estrogens in certain tissues while remaining inert or acting as an anti-estrogen in other tissues has opened up opportunities for treating specific estrogen-modulated diseases without accepting the risk of systemic estrogen activity. SERM development has resulted in significant therapeutic advances for breast cancer, osteoporosis and potentially other diseases associated with the menopause. After the publication of the Women's Health Initiative, interest in compound selectivity that reduces menopausal symptoms while protecting bone, breast, uterus and the heart has increased. Future SERMs may also have a therapeutic profile that can be tailored to specific patient populations, including men. This review paper summarizes the characteristics of different SERMs from various pharmacological categories and the feasibility and scope of their use for a large range of disease/health conditions.
- Subjects :
- Male
Selective Estrogen Receptor Modulators
Eye Diseases
Headache Disorders
medicine.drug_class
Osteoporosis
Pharmacology
Cognition
Breast cancer
Neoplasms
Humans
Medicine
Osteoporosis, Postmenopausal
Uterine Diseases
Molecular Structure
business.industry
Obstetrics and Gynecology
Venous Thromboembolism
General Medicine
Antiestrogen
medicine.disease
Thrombocytopenia
Cholesterol
Selective estrogen receptor modulator
Estrogen
Infertility
Vagina
Gynecomastia
Female
Atrophy
Menopause
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14730804 and 13697137
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Climacteric
- Accession number :
- edsair.doi.dedup.....6370f6b2fe1c297201925af4438128c6