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Synthesis and Chemiluminescent High Throughput Screening for Inhibition of Acetylcholinesterase Activity by Imidazo[2,1-b]thiazole Derivatives
- Source :
- ChemInform. 37
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- The synthesis of a new series of imidazo[2,1-b]thiazole derivatives is described. They were tested as acetylcholinesterase inhibitors by means of a chemiluminescent method suitable for high throughput screening. The compounds without quaternization had no appreciable inhibitory potency probably because they are poorly soluble in water. The corresponding quaternized compounds were good inhibitors with activity related to the spacer employed.
- Subjects :
- medicine.drug_class
IMIDAZO[2
High-throughput screening
Neuromuscular transmission
Drug Evaluation, Preclinical
Carboxamide
Chemical synthesis
Sensitivity and Specificity
law.invention
Structure-Activity Relationship
chemistry.chemical_compound
law
Drug Discovery
medicine
Organic chemistry
Thiazole
Chemiluminescence
Pharmacology
biology
Bicyclic molecule
Molecular Structure
ALZHEIMERE'S DISEASE
Organic Chemistry
Imidazoles
General Medicine
Combinatorial chemistry
Acetylcholinesterase
BISAMMONIUM SALT
Thiazoles
Inhibitory potency
ANTIACETYLCHOLINESTERASE ACTIVITY
chemistry
Enzyme inhibitor
CHEMILUMINESCENT
Luminescent Measurements
biology.protein
1-B]THIAZOLE
Subjects
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi.dedup.....6356a2fc1e501863a883982470ab7209