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Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China
- Source :
- The Journal of Infectious Diseases
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated the serum cytokine and chemokine levels in asymptomatic, mild, moderate, severe, and convalescent SARS-CoV-2–infected cases. Proinflammatory cytokine and chemokine production induced by SARS-CoV-2 were observed not only in symptomatic patients but also in asymptomatic cases, and returned to normal after recovery. IL-6, IL-7, IL-10, IL-18, G-CSF, M-CSF, MCP-1, MCP-3, IP-10, MIG, and MIP-1α were found to be associated with the severity of COVID-19. Moreover, a set of cytokine and chemokine profiles were significantly higher in SARS-CoV-2–infected male than female patients. The serum levels of MCP-1, G-CSF, and VEGF were weakly and positively correlated with viral titers. We suggest that combinatorial analysis of serum cytokines and chemokines with clinical classification may contribute to evaluation of the severity of COVID-19 and optimize the therapeutic strategies.<br />The serum levels of IL-6, IL-7, IL-10, IL-18, G-CSF, M-CSF, IP-10, MCP-1, MCP-3, MIG, and MIP-1α were associated with the severity of COVID-19. Men had higher levels of cytokines/chemokines than women. Some cytokines/chemokines were weakly correlated with the viral load.
- Subjects :
- Adult
Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Macrophage colony-stimulating factor
Chemokine
medicine.medical_treatment
Pneumonia, Viral
Severity of Illness Index
Asymptomatic
Proinflammatory cytokine
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Granulocyte Colony-Stimulating Factor
Severity of illness
Major Article
cytokine
medicine
Humans
Immunology and Allergy
AcademicSubjects/MED00860
Pandemics
Chemokine CCL2
biology
SARS-CoV-2
business.industry
chemokine
COVID-19
Middle Aged
Viral Load
Granulocyte colony-stimulating factor
AcademicSubjects/MED00290
030104 developmental biology
Infectious Diseases
Cytokine
030220 oncology & carcinogenesis
Immunology
biology.protein
Cytokines
Female
disease severity
Chemokines
medicine.symptom
Coronavirus Infections
business
Viral load
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 222
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....632b3c3cf64bd04765e8c187a362189f