Back to Search
Start Over
Three step synthesis of single diastereoisomers of the vicinal trifluoro motif
- Source :
- Beilstein Journal of Organic Chemistry, Beilstein Journal of Organic Chemistry, Vol 5, Iss 1, p 61 (2009)
- Publication Year :
- 2009
-
Abstract
- A three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-α,β-epoxy alcohols and takes a direct approach in that each of the three steps introduces a fluorine atom in a regio- and stereo-specific manner. Starting from either the syn- or the anti-α,β-epoxy alcohol, stereospecific reactions generate two separate diastereoisomeric series of this motif. The route is a significant improvement on an earlier six step strategy.
- Subjects :
- Stereochemistry
C-F bond
Full Research Paper
Kinetic resolution
lcsh:QD241-441
Hydrogen-fluoride
chemistry.chemical_compound
Stereospecificity
lcsh:Organic chemistry
Fluorination
C–F bond
Epoxides
QD
lcsh:Science
organo–fluorine chemistry
Bond
organo-fluorine chemistry
Trifluoromethyl
Chemistry
Organic Chemistry
Diastereomer
QD Chemistry
vicinal trifluoro motif
stereospecific fluorination
lcsh:Q
Vicinal
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Beilstein Journal of Organic Chemistry, Beilstein Journal of Organic Chemistry, Vol 5, Iss 1, p 61 (2009)
- Accession number :
- edsair.doi.dedup.....63169462803ad319113a106d547de62f