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Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease
- Source :
- Journal of Pharmacy and Pharmacology. 69:1219-1229
- Publication Year :
- 2017
- Publisher :
- Oxford University Press (OUP), 2017.
-
Abstract
- Objectives The aim of this work was to assess the possible beneficial effects of aqueous extracts of Hibiscus sabdariffa L. calyces and anthocyanins isolated therefrom in an adenine-induced chronic kidney disease (CKD) model. Methods Rats were orally given, for 28 consecutive days, either adenine alone or together with either aqueous extract of H. sabdariffa calyces (5 and 10%) or anthocyanins (50, 100 and 200 mg/kg of anthocyanin concentrate). For comparative purposes, two groups of rats were given lisinopril (10 mg/kg). Key findings When either H. sabdariffa aqueous extract or the anthocyanins isolated from it was administered along with adenine, the adverse effects of adenine-induced CKD were significantly lessened, mostly in a dose-dependent manner. The positive effects were similar to those obtained by administration of lisinopril. Conclusions The results obtained show that both H. sabdariffa and its anthocyanins could be considered as possible promising safe dietary agents that could be used to attenuate the progression of human CKD. This could have added significance as H. sabdariffa tea is widely consumed in many parts of Africa and Asia and is thus readily available.
- Subjects :
- Male
0301 basic medicine
030232 urology & nephrology
Administration, Oral
Pharmaceutical Science
Anthocyanins
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Lisinopril
Botany
Animals
Medicine
Rats, Wistar
Renal Insufficiency, Chronic
Beneficial effects
Malvaceae
Pharmacology
Aqueous extract
Dose-Response Relationship, Drug
Traditional medicine
biology
Plant Extracts
business.industry
Adenine
Hibiscus sabdariffa
Hibiscus
biology.organism_classification
medicine.disease
Rats
Disease Models, Animal
030104 developmental biology
chemistry
Anthocyanin
business
medicine.drug
Kidney disease
Subjects
Details
- ISSN :
- 20427158 and 00223573
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacy and Pharmacology
- Accession number :
- edsair.doi.dedup.....63021ea7a2296b3df7ffbfed9f5af113