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Can milk proteins be a useful tool in the management of cardiometabolic health? An updated review of human intervention trials
- Source :
- The Proceedings of the Nutrition Society. 75(3)
- Publication Year :
- 2016
-
Abstract
- The prevalence of cardiometabolic diseases is a significant public health burden worldwide. Emerging evidence supports the inverse association between greater dairy consumption and reduced risk of cardiometabolic diseases. Dairy proteins may have an important role in the favourable impact of dairy on human health such as blood pressure (BP), blood lipid and glucose control. The purpose of this review is to update and critically evaluate the evidence on the impacts of casein and whey protein in relation to metabolic function. Evidence from short-term clinical studies assessing postprandial responses to milk protein ingestion suggests benefits on vascular function independent of BP, as well as improvement in glycaemic homeostasis. Long-term interventions have been less conclusive, with some showing benefits and others indicating a lack of improvement in vascular function. During chronic consumption BP appears to be lowered and both dyslipidaemia and hyperglacaemia seem to be controlled. Limited number of trials investigated the effects of dairy proteins on oxidative stress and inflammation. Although the underlying mechanisms of milk proteins on cardiometabolic homeostasis remains to be elucidated, the most likely mechanism is to improve insulin resistance. The incorporation of meals enriched with dairy protein in the habitual diet may result in the beneficial effects on cardiometabolic health. Nevertheless, future well-designed, controlled studies are needed to investigate the relative effects of both casein and whey protein on BP, vascular function, glucose homeostasis and inflammation.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Medicine (miscellaneous)
Blood lipids
Blood Pressure
030204 cardiovascular system & hematology
Bioinformatics
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Randomized controlled trial
Meta-Analysis as Topic
law
Casein
Internal medicine
medicine
Glucose homeostasis
Humans
Randomized Controlled Trials as Topic
Inflammation
Metabolic Syndrome
030109 nutrition & dietetics
Nutrition and Dietetics
Lactotripeptides
biology
business.industry
C-reactive protein
Caseins
medicine.disease
Lipid Metabolism
Postprandial Period
Diet
Oxidative Stress
Endocrinology
Postprandial
Whey Proteins
chemistry
Cardiovascular Diseases
Glycemic Index
biology.protein
business
Subjects
Details
- ISSN :
- 14752719
- Volume :
- 75
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Proceedings of the Nutrition Society
- Accession number :
- edsair.doi.dedup.....62f6c51ac86d6d1ef4829435638e61d8