Back to Search
Start Over
Comparative efficacy in red blood cell exchange transfusions with different apheresis machines in patients with sickle cell disease
- Publication Year :
- 2017
- Publisher :
- Springer India, 2017.
-
Abstract
- The purpose of this study is to compare the efficacy and side effects of two red blood cell exchange (RBCX) transfusion systems in sickle cell disease (SCD). The data is collected retrospectively from the January 2010 to March 2015. 447 RBCX transfusions were performed to 165 patients. Side effects, clinical and technical efficacy were compared in between procedures with Cobe Spectra (CS) and Spectra Optia (SO) systems. Furthermore a subgroup analyses was performed for 40 patients who had RBCX transfusions with both system at least two times. Vasoocclusive crises, preoperative period and foot ulcers (49.6, 13, and 15.2% respectively) were the common indications of RBCX transfusion. While the levels of post-RBCX HbS and the actual fraction of cells remaining (FCRa) were found significantly higher in the SO compared to CS system (p = 0.018 and p = 0.016 respectively), the rate of targeted hemoglobin S (HbS) levels (
- Subjects :
- medicine.medical_specialty
Hematology
business.industry
Cell
Disease
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
Red blood cell
0302 clinical medicine
medicine.anatomical_structure
Apheresis
Cobe spectra
Internal medicine
medicine
In patient
Original Article
Foot ulcers
business
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....62ed4635b71f19a36256546123721c41