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Kidins220/ARMS controls astrocyte calcium signaling and neuron–astrocyte communication
- Source :
- Cell Death Differ
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- Through their ability to modulate synaptic transmission, glial cells are key regulators of neuronal circuit formation and activity. Kidins220/ARMS (kinase-D interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning) is one of the key effectors of the neurotrophin pathways in neurons where it is required for differentiation, survival, and plasticity. However, its role in glial cells remains largely unknown. Here, we show that ablation of Kidins220 in primary cultured astrocytes induced defects in calcium (Ca(2+)) signaling that were linked to altered store-operated Ca(2+) entry and strong overexpression of the transient receptor potential channel TRPV4. Moreover, Kidins220(−/−) astrocytes were more sensitive to genotoxic stress. We also show that Kidins220 expression in astrocytes is required for the establishment of proper connectivity of cocultured wild-type neurons. Altogether, our data reveal a previously unidentified role for astrocyte-expressed Kidins220 in the control of glial Ca(2+) dynamics, survival/death pathways and astrocyte–neuron communication.
- Subjects :
- 0301 basic medicine
TRPV4
Neurogenesis
astrocyte culture, calcium signal, neuron-astrocyte interaction
TRPV Cation Channels
Cell Communication
Neurotransmission
calcium signaling
Models, Biological
Article
03 medical and health sciences
Transient receptor potential channel
astrocyte
0302 clinical medicine
medicine
Ankyrin
Animals
Humans
astrocytes
Kidins220/ARMS
Calcium Signaling
Molecular Biology
Cells, Cultured
Calcium signaling
chemistry.chemical_classification
Neurons
biology
Chemistry
Membrane Proteins
Cell Biology
Embryo, Mammalian
Cell biology
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
nervous system
030220 oncology & carcinogenesis
Astrocytes
biology.protein
Calcium
Neuron
Astrocyte
Neurotrophin
DNA Damage
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cell Death Differ
- Accession number :
- edsair.doi.dedup.....62c9a26ef2acca6471260307e25bee13