New Perspectives for the Rescue of Cognitive Disability in Down Syndrome

Authors :: Diana W. Bianchi
Tarik F. Haydar
Mara Dierssen
Jean-Maurice Delabar
Carmen Martínez-Cué
Renata Bartesaghi
Bartesaghi, Renata
Haydar, Tarik F.
Delabar, Jean Maurice
Dierssen, Mara
Martinez-Cué, Carmen
Bianchi, Diana W.
Universidad de Cantabria
Source :: Journal of neuroscience, October 14, 2015; 35(41): 13843-13852, UCrea Repositorio Abierto de la Universidad de Cantabria, Universidad de Cantabria (UC)
Publication Year :: 2015
Publisher :: Society for Neuroscience, 2015.
Abstract: Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.

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