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Utility of Coagulation Markers for the Prediction of Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis
- Source :
- Lung. 197:437-442
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- We aimed to evaluate the utility of coagulation markers for the prediction of rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). In this retrospective study, 29 patients with DM-associated ILD were analyzed. The number of patients with RP-ILD was 15 (52%). The baseline clinical and demographic data and laboratory markers were analyzed to identify predictive factors for RP-ILD.The univariate logistic regression analysis demonstrated that in addition to well-known laboratory markers, such as serum ferritin, KL-6, and lymphocyte counts, a prolonged activated partial thromboplastin time (aPTT) ratio at the time of DM-associated ILD diagnosis was useful for predicting RP-ILD. Moreover, the logistic regression model and receiver operating characteristic curve analysis showed that combinations of the aPTT ratio and well-known laboratory markers were significantly effective in predicting RP-ILD. This study suggested that an association between RP-ILD and the coagulation system exists.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Time Factors
Lymphocyte
Logistic regression
Risk Assessment
behavioral disciplines and activities
Gastroenterology
Dermatomyositis
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
medicine
Humans
Lymphocyte Count
030212 general & internal medicine
Blood Coagulation
Aged
Retrospective Studies
Receiver operating characteristic
medicine.diagnostic_test
business.industry
Mucin-1
Interstitial lung disease
Retrospective cohort study
Middle Aged
respiratory system
medicine.disease
respiratory tract diseases
body regions
medicine.anatomical_structure
030228 respiratory system
Coagulation
Ferritins
Disease Progression
Female
Partial Thromboplastin Time
Lung Diseases, Interstitial
business
Biomarkers
Partial thromboplastin time
Subjects
Details
- ISSN :
- 14321750 and 03412040
- Volume :
- 197
- Database :
- OpenAIRE
- Journal :
- Lung
- Accession number :
- edsair.doi.dedup.....62b103ad73aae3d373a6cae28ad86162