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Cellular therapies in kidney transplantation
- Source :
- Current Opinion in Nephrology & Hypertension. 30:584-592
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- PURPOSE OF REVIEW Current immunosuppressive regimens used in kidney transplantation are sometimes ineffective and carry significant risks of morbidity and mortality. Cellular therapies are a promising alternative to prolong graft survival while minimizing treatment toxicity. We review the recently published breakthrough studies using cell therapies in kidney transplantation. RECENT FINDINGS The reviewed phase I and II trials showed that cell therapies are feasible and safe in kidney transplantation, sometimes associated with less infectious complications than traditional regimens. Regulatory T cells and macrophages were added to the induction regimen, allowing for lower immunosuppressive drug doses without higher rejection risk. Regulatory T cells are also a treatment for subclinical rejection on the 6 months biopsy. Other strategies, like bone marrow-derived mesenchymal cells, genetically modified regulatory T cells, and chimerism-based tolerance are also really promising. In addition, to improve graft tolerance, cell therapy could be used to prevent or treat viral infection after transplantation. SUMMARY Emerging data underline that cell therapy is a feasible and safe treatment in kidney transplantation. Although the evidence points to a benefit for transplant recipients, studies with standardized protocols, representative control groups, and longer follow-up are needed to answer the question definitively and guide future research.
- Subjects :
- medicine.diagnostic_test
business.industry
medicine.medical_treatment
Graft Survival
Mesenchymal stem cell
Cell- and Tissue-Based Therapy
Bioinformatics
medicine.disease
Chimerism
Kidney Transplantation
Cell therapy
Transplantation
Regimen
Immunosuppressive drug
Nephrology
Biopsy
Internal Medicine
Humans
Medicine
business
Immunosuppressive Agents
Kidney transplantation
Subclinical infection
Subjects
Details
- ISSN :
- 14736543 and 10624821
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Nephrology & Hypertension
- Accession number :
- edsair.doi.dedup.....62a7140bf20e4c0a55f0651ae102cdd4