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The neuropeptide 26RFa in the human gut and pancreas: potential involvement in glucose homeostasis
- Source :
- Endocrine Connections 7 (8), 941-951. (2019), Endocrine Connections, Endocrine Connections, BioScientifica Ltd., 2019, 8 (7), pp.941-951. ⟨10.1530/ec-19-0247⟩, Endocrine Connections, Vol 8, Iss 7, Pp 941-951 (2019), Endocrine Connections, BioScientifica, 2019, 8 (7), pp.941-951. ⟨10.1530/EC-19-0247⟩, Endocrine Connections, 2019, 8 (7), pp.941-951. ⟨10.1530/ec-19-0247⟩
- Publication Year :
- 2019
-
Abstract
- Objective Recent studies performed in mice revealed that the neuropeptide 26RFa regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity. However, in humans, an association between 26RFa and the regulation of glucose homeostasis is poorly documented. In this study, we have thus investigated in detail the distribution of 26RFa and its receptor, GPR103, in the gut and the pancreas, and determined the response of this peptidergic system to an oral glucose challenge in obese patients. Design and methods Distribution of 26RFa and GPR103 was examined by immunohistochemistry using gut and pancreas tissue sections. Circulating 26RFa was determined using a specific radioimmunoassay in plasma samples collected during an oral glucose tolerance test. Results 26RFa and GPR103 are present all along the gut but are more abundant in the stomach and duodenum. In the stomach, the peptide and its receptor are highly expressed in the gastric glands, whereas in the duodenum, ileum and colon they are present in the enterocytes and the goblet cells. In the pancreatic islets, the 26RFa/GPR103 system is mostly present in the β cells. During an oral glucose tolerance test, plasma 26RFa profile is different between obese patients and healthy volunteers, and we found strong positive correlations between 26RFa blood levels and the BMI, and with various parameters of insulin secretion and insulin resistance. Conclusion The present data suggest an involvement of the 26RFa/GPR103 peptidergic system in the control of human glucose homeostasis.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
insulin
obesity
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Incretin
pancréas
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Insulin resistance
intestin
Gastric glands
Internal medicine
Internal Medicine
Medicine
Glucose homeostasis
glucose homeostasis
Food and Nutrition
gut
pancreas
incretin
glucose
ComputingMilieux_MISCELLANEOUS
insuline
homéostasie
lcsh:RC648-665
business.industry
Research
Stomach
Pancreatic islets
Insulin
digestive, oral, and skin physiology
Neurosciences
medicine.disease
[SDV] Life Sciences [q-bio]
obésité
030104 developmental biology
medicine.anatomical_structure
Neurons and Cognition
Alimentation et Nutrition
business
Pancreas
Subjects
Details
- Language :
- English
- ISSN :
- 20493614
- Database :
- OpenAIRE
- Journal :
- Endocrine Connections 7 (8), 941-951. (2019), Endocrine Connections, Endocrine Connections, BioScientifica Ltd., 2019, 8 (7), pp.941-951. ⟨10.1530/ec-19-0247⟩, Endocrine Connections, Vol 8, Iss 7, Pp 941-951 (2019), Endocrine Connections, BioScientifica, 2019, 8 (7), pp.941-951. ⟨10.1530/EC-19-0247⟩, Endocrine Connections, 2019, 8 (7), pp.941-951. ⟨10.1530/ec-19-0247⟩
- Accession number :
- edsair.doi.dedup.....62a4e40cc9f70c1323e607ac39de6399