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Meta-analysis of the clinical and laboratory parameters of SFTS patients in China
- Source :
- Virology Journal
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia, which is caused by a novel bunyavirus-SFTSV. Many studies have reported the clinical characters of SFTS patients, but the reports were not consistent and a systematic summary of clinical manifestations and laboratory parameters are not available. Method A comprehensive literature research of Web of Science, PubMed, Wan Fang Data, and Chinese National Knowledge Infrastructure databases was conducted on articles which have described the clinical characters of SFTS patients. Data from selected studies were pooled by using STATA VERSION 12.0 software. Result Nine articles comprising 844 laboratory-confirmed SFTSV cases were included in this meta-analysis. The pooled case fatality rate was 16% (95% CI: 0.13–0.19). The major clinical characters of patients with SFTSV infection were fever, thrombocytopenia, leucopenia, gastrointestinal symptoms, and central nervous system manifestations. The risk factors for severe disease included bleeding tendency, central nervous system manifestations, elevated serum enzymes, and high viral load. Although there is no specific antiviral therapy for SFTSV infection, symptomatic treatment and supportive therapy including intensive monitoring is the most essential part of case management. Conclusion The major clinical characters of patients with SFTSV infection were fever, thrombocytopenia, leucopenia and gastrointestinal symptoms, and central nervous system manifestations. The risk factors for severity and fatality among SFTS patients included: old age, CNS manifestations, bleeding tendency, elevated serum enzymes, and high vial load.
- Subjects :
- Phlebovirus
Case fatality rate
0301 basic medicine
China
medicine.medical_specialty
030231 tropical medicine
Hemorrhage
Clinical manifestation
03 medical and health sciences
0302 clinical medicine
Central Nervous System Diseases
Risk Factors
Virology
Internal medicine
medicine
Humans
Risk factor
Intensive care medicine
Survival analysis
biology
business.industry
Research
Age Factors
Severe fever with thrombocytopenia syndrome (SFTS)
Viral Load
medicine.disease
biology.organism_classification
Survival Analysis
Severe fever with thrombocytopenia syndrome
Phlebotomus Fever
030104 developmental biology
Infectious Diseases
Supportive psychotherapy
Meta-analysis
business
Viral load
Subjects
Details
- ISSN :
- 1743422X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Virology Journal
- Accession number :
- edsair.doi.dedup.....628e457e0695788e5fc91c1d4ae124e8