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The aging of hematopoietic stem cells
- Source :
- Nature Medicine. 2:1011-1016
- Publication Year :
- 1996
- Publisher :
- Springer Science and Business Media LLC, 1996.
-
Abstract
- We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and compared their properties to HSCs in young and middle-aged mice. Single, reconstituting HSCs (by limit dilution) from old and young mice exhibited indistinguishable progenitor activities in vivo. HSCs were five times as frequent in the bone marrow of old mice; however, HSCs from old mice were only one-quarter as efficient at homing to and engrafting the bone marrow of irradiated recipients. HSCs in young and middle-aged mice rarely were in the S/G2/M phases of the cell cycle, but HSCs in old mice were frequently in cycle. We speculate that the unexpected proliferation of HSCs in old mice might be related to the increased incidence of leukemia in old mice. HSCs change with age, but it is unknown whether these changes are determined intrinsically or caused by the aging of their environment.
- Subjects :
- Aging
Cell Cycle
Stem cell theory of aging
Bone Marrow Cells
hemic and immune systems
General Medicine
Cell cycle
Biology
Hematopoietic Stem Cells
medicine.disease
General Biochemistry, Genetics and Molecular Biology
Mice, Inbred C57BL
Mice
Haematopoiesis
Leukemia
medicine.anatomical_structure
Immunology
medicine
Cancer research
Animals
Bone marrow
Stem cell
Cells, Cultured
Homing (hematopoietic)
Progenitor
Subjects
Details
- ISSN :
- 1546170X and 10788956
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Nature Medicine
- Accession number :
- edsair.doi.dedup.....628d513132355b88215486d58f80aa4d