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Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study

Authors :
Pierluigi Marzuillo
Pier Luigi Palma
Anna Di Sessa
Agnese Roberti
Giovanni Torino
Maeva De Lucia
Emanuele Miraglia del Giudice
Stefano Guarino
Giovanni Di Iorio
Marzuillo, Pierluigi
Palma, Pier Luigi
Di Sessa, Anna
Roberti, Agnese
Torino, Giovanni
De Lucia, Maeva
Miraglia Del Giudice, Emanuele
Guarino, Stefano
Di Iorio, Giovanni
Publication Year :
2023

Abstract

The aim of the study was to evaluate whether serum aldosterone levels or plasmatic renin activity (PRA) measured early in life (1–3 months) could predict a future surgical intervention for obstructive congenital anomalies of kidney and urinary tract (CAKUT). Twenty babies aged 1–3 months of life with suspected obstructive CAKUT were prospectively enrolled. The patients underwent a 2-year follow-up and were classified as patients needing or not needing surgery. In all of the enrolled patients, PRA and serum aldosterone levels were measured at 1–3 months of life and were evaluated as predictors of surgery by receiver-operating characteristic (ROC) curve analysis. Patients undergoing surgery during follow-up showed significantly higher levels of aldosterone at 1–3 months of life compared to those who did not require surgery (p = 0.006). The ROC curve analysis of the aldosterone for obstructive CAKUT needing surgery showed an area under the ROC curve of 0.88 (95%CI = 0.71–0.95; p = 0.001). The aldosterone cut-off of 100 ng/dL presented 100% sensitivity and 64.3% specificity and predicted surgery in 100% of cases. The PRA at 1–3 months of life was not a predictor of surgery. In conclusion, serum aldosterone levels at 1–3 months could predict the need for surgery during obstructive CAKUT follow-up.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....62894be5a334e0359e408899dc09dfb7