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Translocation (3;21)(q26;q22) in treatment-related acute leukemia secondary to acute promyelocytic leukemia
- Source :
- Cancer Genetics and Cytogenetics. 74:84-86
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- We performed cytogenetic studies in a patient with treatment-related acute leukemia (t-AL) to identify the associated chromosomal changes. Metaphase analysis revealed a t(3;21)(q26;q22) translocation. Acute promyelocytic leukemia (APL) had been diagnosed 4 years earlier and the patient had received intensive induction chemotherapy and sequential post-induction therapy that included agents that targeted DNA-topoisomerase II (topo II). This case suggests an association between previous therapy with topo II inhibitors and development of t-AL associated with a balanced aberration involving the 3q26 and 21q22 bands.
- Subjects :
- Male
Acute promyelocytic leukemia
Cancer Research
Acute leukemia
Chemotherapy
Leukemia
medicine.medical_treatment
Induction chemotherapy
Chromosomal translocation
Middle Aged
Biology
medicine.disease
Neoplasms, Multiple Primary
Leukemia, Promyelocytic, Acute
Karyotyping
Acute Disease
Genetics
medicine
Cancer research
Humans
Topoisomerase II Inhibitors
Prolymphocytic leukemia
Molecular Biology
Metaphase
Subjects
Details
- ISSN :
- 01654608
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Cancer Genetics and Cytogenetics
- Accession number :
- edsair.doi.dedup.....62792a092b25caae8ad0b69ed6bcc2d0