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Establishment and validation of a nomogram model for aseptic loosening after tumor prosthetic replacement around the knee: a retrospective analysis
- Source :
- Journal of Orthopaedic Surgery and Research, Vol 14, Iss 1, Pp 1-9 (2019), Journal of Orthopaedic Surgery and Research
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background Aseptic loosening has become the main cause of prosthetic failure in medium- to long-term follow-up. The objective of this study was to establish and validate a nomogram model for aseptic loosening after tumor prosthetic replacement around knee. Methods We collected data on patients who underwent tumor prosthetic replacements. The following risk factors were analyzed: tumor site, stem length, resection length, prosthetic motion mode, sex, age, extra-cortical grafting, custom or modular, stem diameter, stem material, tumor type, activity intensity, and BMI. We used univariate and multivariate Cox regression for analysis. Finally, the significant risk factors were used to establish the nomogram model. Results The stem length, resection length, tumor site, and prosthetic motion mode showed a tendency to be related to aseptic loosening, according to the univariate analysis. Multivariate analysis showed that the tumor site, stem length, and prosthetic motion mode were independent risk factors. The internal validation indicated that the nomogram model had acceptable predictive accuracy. Conclusions A nomogram model was developed for predicting the prosthetic survival rate without aseptic loosening. Patients with distal femoral tumors and those who are applied with fixed hinge and short-stem prostheses are more likely to be exposed to aseptic loosening.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
lcsh:Diseases of the musculoskeletal system
Adolescent
Aseptic loosening
Bone Neoplasms
Young Adult
03 medical and health sciences
0302 clinical medicine
lcsh:Orthopedic surgery
Humans
Medicine
Orthopedics and Sports Medicine
Knee
Risk factor
Tumor prosthesis
Nomogram model
Survival rate
Aged
Retrospective Studies
Osteosarcoma
030222 orthopedics
Univariate analysis
business.industry
Proportional hazards model
Osteonecrosis
Middle Aged
Nomogram
Prosthesis Failure
Surgery
Nomograms
lcsh:RD701-811
030220 oncology & carcinogenesis
Orthopedic surgery
Female
lcsh:RC925-935
Knee Prosthesis
business
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Orthopaedic Surgery and Research
- Accession number :
- edsair.doi.dedup.....627864e8400e984b98e41250f0591af0